Akademik Veri Yönetim Sistemi
South African Journal Of Botany, cilt.141, sa.2021, ss.145-151, 2021 (SCI-Expanded)
Diabetes Mellitus is a global health problem that leads to various complications associated with hyperglycemia.
In traditional medicine, herbal treatment is one of the alternative ways to cope with this type of disease. The
aim of this study is to investigate the antidiabetic and hepato-pancreatic protective effects of the mixture of
Prunus spinosa leaves and flowers (PSE) extract in streptozocin-induced diabetes mellitus. Seven random
experimental groups of Wistar rats (n = 8) were created as followed; control, diabetic, PSE25, PSE50, insulin,
metformin, and acarbose. a-amylase and a-glucosidase inhibitory activities of PSE were determined. Antioxidant
enzymes activities and lipid peroxidation were analyzed in the liver tissue. Histopathological examination
of liver and pancreas was also performed. a-amylase and a-glucosidase IC50 inhibition values of PSE were
found more efficient, comparing to those of standard acarbose. While blood glucose levels severely increased
in all diabetic groups, PSE25 and PSE50 treatments were effective in regulating blood glucose levels. Moreover,
administration of PSE25 and PSE50 improved insulin levels compared to the diabetic group. Although increased
oxidative stress in the diabetes seriously suppressed antioxidant activities, PSE25 and PSE50 supplementation
significantly recuperated liver antioxidant capacity. Despite severe degenerative and necrotic changes in diabetes,
these findings alleviated with PSE administrations. Moreover, PSE treatments remarkably recuperated
b-cells. These results reveal that there may be an alternative way to control high blood glucose levels, which is
one of the most important complications of diabetes. Furthermore, PSE can provide a protection against oxidative
stress, liver and pancreatic damage by augmenting antioxidant capacity in diabetes.