İshalli buzağılarda sistatin C'nin bazı hematolojik ve biyokimyasal parametrelerle ilişkisi


Thesis Type: Postgraduate

Institution Of The Thesis: Van Yüzüncü Yil University, Sağlık Bilimleri Enstitüsü, İç Hastalıkları (Veteriner) (Yl) (Tezli), Turkey

Approval Date: 2019

Thesis Language: Turkish

Student: MOHANAD MAKDAM

Consultant: Yıldıray Başbuğan

Abstract:

The purpose of this research is to determine the relationship between cystatin C (Cys-C) and some hematologic and biochemical parameters in neonatal calves diarrhea. The research topic has been approved by Van YUHADYEK at 28.03.2019 and numbered as 2019/03. In this research the animal material of the study was obtained from different breeds, genders and ages (0-30 days) 10 samples have been taken from healty neonatal calves and 22 samples from diarrhea calves which didn′t recieved any medicine. Otherwise, the general examination has been done for all the calves. Furthermore, by performing etiological examination on the diarrhea calves 3 Giardia, 5 E. coli K99 , 8 Coronavirus, 7 Rotavirus ve 1 Cryptosporidium have been detected. The levels of hematologic (WBC, Neu, Lym, Eo Mo, RBC, MCV, MCHC, Hct, Hb), biochemical (glucose, TP, Alb, BUN, Cr, CK) and blood gas (pH, pO2, pCO2, HCO3-, base, Na+, K+ ve Cl-) have been determind for both healthy calves and neonatal calves diarrhea. Depending on the control group, we have observed that the neonatal calves diarrhea hematologic parameters WBC, Neu, Hct, Hb levels (p<0.05) and biochemical parameter BUN (p<0.01) and Cr (p<0.05) level statistically have been increased. On the other hand, Alb (p<0,05) and glucose (p<0.01) levels have been decreased. In term of blood gas anlaysis and depending on the control group the level of K+ (p<0.05) has been increased , the levels of pH, pO2 and base (p<0.05) have been decreased. We evaluate the Cys-C level in the neonatal calves diarrhea and we have found that Cys-C level is statistically increased this was detected comparing to the control group (p <0.01). As a result; in this research the obtained level of Cys-C can be used as referance for calves; statistically there is no relationship between Cys-C and some of the hematologic and biochemical parameters, the Cys-C level in the calves diarrhea is an important parameter it can be used to determine the diagnosis, treatment and prognosis of the disease; but still much more research about the topic should be done. Key Words:Neonatal calf, Diarrhea, Cystatin C