Effect of genotype imputation on genome-enabled prediction of complex traits: an empirical study with mice data

Felipe V. P. S., Okut H., Gianola D., Silva M. A., Rosa G. J. M.

BMC GENETICS, cilt.15, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1186/s12863-014-0149-9
  • Dergi Adı: BMC GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Background: Genotype imputation is an important tool for whole-genome prediction as it allows cost reduction of individual genotyping. However, benefits of genotype imputation have been evaluated mostly for linear additive genetic models. In this study we investigated the impact of employing imputed genotypes when using more elaborated models of phenotype prediction. Our hypothesis was that such models would be able to track genetic signals using the observed genotypes only, with no additional information to be gained from imputed genotypes.