Catalase Activity, Serum Trace Element and Heavy Metal Concentrations, and Vitamin A, D and E Levels in Pre-eclampsia

Kolusari A., KURDOGLU M., Yildizhan R., ADALI E., EDIRNE T., CEBI A., ...Daha Fazla

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.36, sa.6, ss.1335-1341, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1177/147323000803600622
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1335-1341
  • Anahtar Kelimeler: PRE-ECLAMPSIA, CATALASE, TRACE ELEMENT, HEAVY METAL, VITAMIN A, VITAMIN D, VITAMIN E, ENDOTHELIAL DYSFUNCTION, PLASMA-CONCENTRATIONS, OXIDATIVE STRESS, WOMEN, PREGNANCY, LEAD, ZINC, IRON, EXPOSURE, DAMAGE
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Catalase (antioxidant enzyme) activity in erythrocytes and serum levels of trace elements (copper, iron, zinc), heavy metals (cadmium, cobalt) and vitamins A (retinol), D (cholecalciferol) and E (alpha-tocopherol) were measured in 145 subjects comprising 47 pre-eclamptic pregnant women (PE), 48 healthy pregnant women (HP) and 50 healthy non-pregnant controls (NP). Catalase, vitamins A, D and E and levels of cobalt were significantly lower in the PE group compared with the HP and NP groups, whereas levels of copper, iron and cadmium were significantly higher in the PE group than in the HP and NP groups. Levels of zinc were significantly lower in both the PE and HP groups compared with the NP group. This assessment of oxidant/antioxidant imbalance in pregnant women could be useful in the early identification of pre-eclampsia and antioxidant supplementation in the early weeks of gestation might be useful.