Regulation of Glutathione S-Transferase Mu with type 1 diabetes and its regulation with antioxidants


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Sadi G., Kartal D., GÜRAY N. T.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.38, no.1, pp.92-100, 2013 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.5505/tjb.2013.96720
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.92-100
  • Keywords: GST-Mu, gene expression, lipid peroxidation, protein carbonylation, diabetes mellitus, ALPHA-LIPOIC ACID, OXIDATIVE STRESS, LIPID-PEROXIDATION, ENZYME-ACTIVITIES, GENE-EXPRESSION, VITAMIN-C, RATS, PROTECTION, LOCALIZATION, MODULATION

Abstract

Objective: Increased oxidative stress is now related with the pathogenesis and the chronic complications associated with the disease, diabetes mellitus. While roles of oxidative stress in diabetic complications are widely studied, the molecular mechanisms playing role in the regulations of detoxification enzymes in the presence of antioxidants have not been clearly established because of the complexity of the pathways.