Tez Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Türkiye
Tez Danışmanı: Metin Balcı
Tezin Onay Tarihi: 2016
Tezin Dili: İngilizce
Desteklendiği Program: Diğer
Özet:
A new methodology was developed for the synthesis of dipyrromethane and diazepine
derivatives. In the first section of this thesis, synthesis of various dipyrromethanes
from aromatic aldehydes was carried out. Dipyrromethanes were used as starting
materials for the next step. In the second part of the study, introduction of a propargyl
group to nitrogen atom to one of pyrrole units of dipyrromethane gave the expected
mono-propargylated compounds which were the key compounds for further
cyclization reactions. Base-supported cyclization resulted in the formation of the target
compounds, new diazepine derivatives, via metal-free 7-exo-dig cyclization.