Protective effect of dapagliflozin on colistin-induced renal toxicity


Bora E. S. , ERDOĞAN M. A. , Meral A. , Karakaya Z., Erbas O.

SIGNA VITAE, vol.17, no.4, pp.92-97, 2021 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.22514/sv.2021.020
  • Title of Journal : SIGNA VITAE
  • Page Numbers: pp.92-97

Abstract

Objectives: Multiple-drug resistance to Gram-negative bacteria has increased significantly in recent years. Colistin is increasingly used as a last line of defense against these bacteria. However, colistin has been associated with nephrotoxicity in experimental animals. This study explores the protective effect of dapagliflozin in a rodent model of nephrotoxicity.