Journal Of Orofacial Orthopedics-Fortschritte Der Kieferorthopadie, vol.82, pp.143-152, 2021 (Journal Indexed in SCI Expanded)
Objective The goal of this study was to compare the effects of ibuprofen and low-level laser therapy in alleviating
orthodontic pain observed after elastomeric separator placement (ESP) by means of the analysis of interleukin 1-beta
(IL-1β) and substance P (SP) levels in gingival crevicular fluid (GCF) and visual analog scale (VAS).
Materials and methods A total of 60 subjects requiring ESP for the banding of maxillary first molars were randomly
assigned to the ibuprofen, laser, and control groups. The ibuprofen and control groups received, respectively, 400mg
ibuprofen and placebo lactose tablets orally 1 h before ESP; the laser group received a single low-level laser irradiation
session immediately after ESP. GCF samples were collected immediately after ESP (day 0) and on days 1, 3, and 7. Pain
intensity was evaluated using the VAS immediately after ESP (baseline) and at hours 2 and 6, as well as on days 1, 3,
Results Although IL-1β levels increased significantly on days 1, 3, and 7 compared to day 0, intergroup comparison
results revealed insignificant differences. SP levels indicated insignificant within-group differences. Only the SP levels of
the ibuprofen group showed a significant decrease on days 0 and 1 compared to the laser and control groups. In all groups,
VAS scores increased from baseline to a peak level on day 1, followed by a significant decrease on days 3 and 7. Intergroup
comparison results of VAS scores indicated less pain intensity in the ibuprofen group compared to the control group at
Conclusions Only the ibuprofen group exhibited significant decreases in SP levels on days 0 and 1, as well as in VAS
scores at baseline.