Remission of Cushing's disease with growth hormone replacement

Ozturk M., Atmaca M.

GROWTH HORMONE & IGF RESEARCH, cilt.21, sa.4, ss.238-241, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.ghir.2011.05.005
  • Dergi Adı: GROWTH HORMONE & IGF RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.238-241
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Treatment of Cushing's disease is often challenging. The success rates are not satisfactory and therapeutic interventions frequently causes hypopituitarism. We present three cases of remitting Cushing's disease complicated with growth hormone deficiency. Surprisingly, growth hormone replacement resulted in complete clinical and laboratory remission of Cushing's disease in these patients. However, one of the patients died of myocardial infarction. Effects of growth hormone on cortisol metabolism are discussed. (C) 2011 Elsevier Ltd. All rights reserved.