Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Van Yüzüncü Yıl Üniversitesi, Sağlık Bilimleri Enstitüsü, Farmakoloji (Yl) (Tezli) (Tıp), Türkiye
Tezin Onay Tarihi: 2021
Tezin Dili: Türkçe
Öğrenci: REZZAN TEMELLİ GÖÇEROĞLU
Danışman: Hülya Özdemir
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Özet:
Temelli Göçeroğlu R. The effect of boron on learning
and memory in an Alzhemir type dementia rat model induced by scopolamine. Yuzuncu Yil University
Institute of Health Sciences, M. Sc. Thesis in Department of Pharmacology, Van,
2020. This study was designed to investigate the
effects of boron on Alzheimer type dementia by inducing Alzheimer's-type
dementia in rats. Fifty six Wistar female rats with weight of 250-300 grams
were used in the study. The rats were divided into 7 groups of 8 rats in each
group.
Group
1: control group, was not exposed to any substance or interference. Group 2: %
0,9 NaCI-solvent group, was not exposed to demetia. Group 3: dementia group,
rats were administered scopolamine at a dose of 1 mg/kg 30 minutes before
behavioral experiments. Group 4: Boron 5
mg/kg + scopolamine group, 5 mg/kg/day boron treated rats were given
scopolamine at a dose of 1 mg/kg 30 minutes before behavioral experiments.
Group 5: Boron 10 mg/kg + scopolamine group, 10
mg/kg/day boron treated rats were given scopolamine at a dose of 1 mg/kg 30
minutes before behavioral experiments. Group 6:
Boron 20 mg/kg + scopolamine group, 20 mg/kg/day boron treated rats
were given scopolamine at a dose of 1 mg/kg 30 minutes before behavioral
experiments. Group 7: Galantamine + scopolamine group, 1,5 mg/kg/day
galantamine treated rats were given scopolamine at a dose of 1 mg/kg 30 minutes
before behavioral experiments. The time spent in
the open arms and the number of entries in the open arms in the elevated plus-maze
test were significantly lower in the dementia group than in the control group.
From these values, the time spent in the open field increased in the Boron 20
mg/kg group, and the number of entries in the open arms increased in the Boron
5 mg/kg group. In the morris water maze, the time to find the platform
increased significantly in the dementia group compared to the control. These
values showed reductions in the treatment groups compared to the dementia
group. No difference was found in the Y maze test
results between groups. The results of this study indicate that;
dementia model can be created with scopolamine, boron may have anxiolytic
effects; the effect of boron on learning and memory damage that may develop due
to dementia may vary depending on the dose and boron has no effect on
short-term memory. Considering the multiple effects of boron on
organisms, both the molecular basis of these effects will be elucidated and new
beneficial mechanisms of action of boron in damaged pathophysiological conditions
in humans will be revealed with further studies.
Key words: Alzheimer, Boron, , Dementia,
Scopolamine, Rat.