Studies on reactions of pyrimidine compounds. 2. Microwave-assisted synthesis of 1,2,3,4-tetrahydro-2-thioxopyrimidine derivatives


Aklbas E., ASLANOGLU F.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.183, no.1, pp.82-89, 2008 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 183 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1080/10426500701557021
  • Journal Name: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.82-89

Abstract

The 5-benzoyl-4,6-diphenyl-1,2,3,4-tetrahydro-2-thioxopyrimidine (la) and 5-benzoyl-4-(2-chlorophenyl)-6-phenyl-1,2,3,4-tetrahydro-2-thioxopyrimidine (1b) were synthesized using the Biginelli three-component cyclocondensation reaction of a beta-diketone, arylaldehyde, and thiourea under microwave irradiation. Thiazolopyrimidine (2), (3) and pyrimido[2,3-b]thiazine (4) derivatives were obtained by a Simple one-pot condensation reaction of starting compound 1b and 2-bromopropionic acid, bromoacetic acid and 3-bromopropionic acid, respectively. These reactions performed under microwave irradiation and conventional conditions.