Potential diagnostic and prognostic significance of plasma prolidase activity in gastric cancer


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Çelik S., Kızıltan R., Yilmaz E. M. , Yılmaz Ö., Demir H.

BIOMARKERS IN MEDICINE, vol.11, no.4, pp.319-327, 2017 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.2217/bmm-2016-0367
  • Journal Name: BIOMARKERS IN MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.319-327
  • Keywords: enzymes, gastric cancer, prognostic factors, prolidase activity, tumor markers, OXIDATIVE STATUS, JAPAN

Abstract

Aim: Plasma prolidase activities (PPAs) in cases of gastric cancer. Methodology/results:
This study was based on a prospective design. 60 patients with gastric cancer (operable
cases: 48; inoperable: 12) and 60 healthy controls were included in the study. Prolidase
activity was analyzed. The mean PPA levels in the operable, inoperable and control
groups were 45.60 ± 4.20, 54.35 ± 4. 9 and 10.92 ± 0.79 U/l, respectively (p < 0.001).
PPA decreased significantly after tumor resection. PPA level was significant in
differentiating operable cases from inoperable (sensitivity: 91.7%; specificity: 85.2%).
Discussion/conclusion: PPA was significantly higher in patients with inoperable gastric
cancer than in operable cases and the control group. A strong correlation was found
between tumor volume and PPA.

Aim: Plasma prolidase activities (PPAs) in cases of gastric cancer. Methodology/results: This study was based on a prospective design. 60 patients with gastric cancer (operable cases: 48; inoperable: 12) and 60 healthy controls were included in the study. Prolidase activity was analyzed. The mean PPA levels in the operable, inoperable and control groups were 45.60 +/- 4.20, 54.35 +/- 4. 9 and 10.92 +/- 0.79 U/l, respectively (p < 0.001). PPA decreased significantly after tumor resection. PPA level was significant in differentiating operable cases from inoperable (sensitivity: 91.7%; specificity: 85.2%).