Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer

Gecit I., Aslan M., Gunes M., PIRINCCI N., ESEN R., Demir H., ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, cilt.138, sa.5, ss.739-743, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 138 Sayı: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s00432-011-1136-4
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.739-743
  • Anahtar Kelimeler: Bladder cancer, Nitric oxide, Total antioxidant status, Malondialdehyde, Prolidase activity, LIPID-PEROXIDATION, EXTRACELLULAR-MATRIX, COLLAGEN-METABOLISM, ANTIOXIDANT STATUS, CELL CARCINOMA, STOMACH-CANCER, BREAST-CANCER, VITAMIN-C, IMINODIPEPTIDURIA, INHIBITORS
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Prolidase is a member of the matrix metalloproteinase family. It plays a major role in collagen turnover, matrix remodeling and cell growth. Nitric oxide (NO) regulates many processes such as collagen synthesis and matrix remodeling. Thus, NO may augment angiogenesis, tumor invasion, and metastasis. The aim of this study was to investigate total antioxidant status (TAS), malondialdehyde (MDA) and NO levels in patients with bladder cancer and to determine their relationship with prolidase activity.