Investigation of in-vitro biocompatibility and in-vivo biodegradability of AM series Mg alloys

COMBA A., ÇİÇEK B., COMBA B., Sancak T., Akveran G. A., Sun Y., ...Daha Fazla

MATERIALS TECHNOLOGY, cilt.37, sa.13, ss.2819-2831, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 13
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/10667857.2022.2081115
  • Dergi Adı: MATERIALS TECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, Chimica, Communication Abstracts, Compendex, Computer & Applied Sciences, INSPEC, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.2819-2831
  • Anahtar Kelimeler: Mg alloy, in-vitro, in-vivo, biodegradability, biomaterial, biocompatibility, MAGNESIUM ALLOYS, MECHANICAL-PROPERTIES, BIOCORROSION BEHAVIOR, CORROSION BEHAVIOR, BONE-FORMATION, DEGRADATION, MICROSTRUCTURE, PHOSPHATE, STRENGTH, MODEL
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

In this study, in vitro/vivo biocompatibility experiments of Mg-Al-Mn alloy were carried out, and AM50 and AM60 alloys were used in the experiments. Immersion and potentiodynamic corrosion have been applied to these alloys in vitro. For biocompatibility, cytotoxicity test was performed. A total of 40 rats were used for the in-vivo experiment. AM series alloys were surgically placed in the femoral condyle as mini screws and monitored radiographically. AM alloys were removed together with the femur at the end of 7 weeks and further examined. After in-vivo application, the biodegradability level was successfully concluded with blood mineral analysis and urinalysis. In this study, the bioprocess of AM series Mg alloys with Al and Mn additions has been completed. As a result, the AM alloys used can be classified as biocompatible and biodegradable materials.