beta-Escin reduces cancer progression in aggressive MDA-MB-231 cells by inhibiting glutamine metabolism through downregulation of c-myc oncogene


Akar S., ALTUNTAŞ H., HAMURCU Z.

MOLECULAR BIOLOGY REPORTS, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1007/s11033-022-07536-5
  • Journal Name: MOLECULAR BIOLOGY REPORTS
  • Journal Indexes: Science Citation Index Expanded, Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Apoptosis, ASCT2, Breast cancer, beta-Escin, Glutamine, GLS1, Migration, c-myc, MDA-MB-231, BREAST-CANCER, SUPPRESSES PROLIFERATION, IN-VITRO, KAPPA-B, APOPTOSIS, RESISTANCE, MIGRATION, INVASION, GEMCITABINE, EXPRESSION

Abstract

Background The c-myc oncogene, which causes glutamine dependence in triple negative breast cancers (TNBC), is also the target of one of the signaling pathways affected by beta-Escin.