beta-Escin reduces cancer progression in aggressive MDA-MB-231 cells by inhibiting glutamine metabolism through downregulation of c-myc oncogene

Akar, Sakine; ALTUNTAŞ, HAMİYET; HAMURCU, ZÜHAL

doi:10.1007/s11033-022-07536-5

beta-Escin reduces cancer progression in aggressive MDA-MB-231 cells by inhibiting glutamine metabolism through downregulation of c-myc oncogene

Akar S., ALTUNTAŞ H., HAMURCU Z.

MOLECULAR BIOLOGY REPORTS, cilt.49, sa.8, ss.7409-7415, 2022 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 49 Sayı: 8
Basım Tarihi: 2022
Doi Numarası: 10.1007/s11033-022-07536-5
Dergi Adı: MOLECULAR BIOLOGY REPORTS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.7409-7415
Anahtar Kelimeler: Apoptosis, ASCT2, Breast cancer, beta-Escin, Glutamine, GLS1, Migration, c-myc, MDA-MB-231, BREAST-CANCER, SUPPRESSES PROLIFERATION, IN-VITRO, KAPPA-B, APOPTOSIS, RESISTANCE, MIGRATION, INVASION, GEMCITABINE, EXPRESSION
Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Background The c-myc oncogene, which causes glutamine dependence in triple negative breast cancers (TNBC), is also the target of one of the signaling pathways affected by beta-Escin.