Design, Synthesis of Pyrrolo[1,2-a]pyrazine Derivatives and Their Antiproliferative Activities on Various Cancer Cell Lines

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Mengeş M. F., Mengeş N., Tan Uygun M.

10. Uluslararası İlaç Kimyası Kongresi , Antalya, Türkiye, 10 - 13 Mart 2022, ss.210

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.210
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Pyrrolo[1,2-a]pyrazines have neuroleptic, cardiovaskular, immunosuppressive, antibacterial, antiinsect defensive properties and are also a potent and selective 5-HT2C receptor agonists and selective 5-HT3 receptor agonists. Furthermore, some clinically used drugs for lung, prostate, and breast cancer, tuberculosis treatment, or inhibitors of glycogen synthase kinase-3β (GSK-3) and protein kinase B1 , have nitrogen-fused scafolds.1 Some pyrrolopyrazine compounds that are useful as inhibitors of ATR protein kinase for cancer treatment have been recently patented.2 Some pharmacologically active pyrrolo[1,2-a]pyrazines are disclosed in the literature, as shown at below. Various imidazopyridine derivatives show cytotoxic activity against glioblastoma cell line (LN-405).3