Synthesis of the 3,5-diphenyl-1H-pyrazole and cytogenetic and oxidative alterations after exposure of cultured human whole blood cells


Akbaş E. , Celikezen F. C. , Turkez H., Ozdemir O., Rüzgar A. , Ergan E. , ...More

COGENT CHEMISTRY, vol.3, no.1, 2017 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1080/23312009.2017.1344115
  • Title of Journal : COGENT CHEMISTRY
  • Keywords: pyrazole, thiosemicarbazide, cytotoxic, INDUCED LIVER-INJURY, BIOLOGICAL EVALUATION, IN-VITRO, REGIOSELECTIVE SYNTHESIS, PYRAZOLE DERIVATIVES, AFLATOXIN B-1, SOLID-STATE, ANTICANCER, TOXICITY, AGENTS

Abstract

The 3,5-diphenyl-1H-pyrazole was obtained by condensation reaction of dibenzoylmethane and thiosemicarbazide in acetic acid under conventional heating and microwave irradiation method. The structure of the 3,5-diphenyl-1H-pyrazole confirmed by IR, H-1, and C-13 NMR and X-ray diffraction and the geometry optimization was carried out using density functional theory (DFT) methods at B3LYP/6-31G, 6-31G(d), 6-31G(d, p), 6-311G(d, p), 6-311G(2d, 2p), 6-31+G(d, p), 6-311++G(d, p) levels. In addition, cytotoxic and oxidative effects were investigated in cultured human peripheral blood cells.