Akademik Veri Yönetim Sistemi
6th World Congress of Oxidative Stress, Calcium Signaling and TRP Channels (6.CMOS-2016), Isparta, Türkiye, 24 - 27 Mayıs 2016, cilt.8, sa.1, ss.574-575
In this study, it were investigated that effects of
thymoquinone (TQ) on antioxidant vitamin levels on
experimental diabetic rats. Twenty-eight male WistarAlbino rats (200-250 g) were used as material. The rats
were divided into four groups of control (C),
thymoquinone (T), diabetes (D) and
diabetes+thymoquinone (DT). D and DT groups were
treated with 45 mg/kg streptozotocin (STZ) (i.p). TQ was administered as 30 mg/kg/21 day by oral gavage in
DT and T groups. It was observed that the retinol
concentrations significantly decreased in the diabetes
and diabetes + TQ groups (p ≤ 0.05). There was no
difference between the group delivered TQ and the
control group. It was identified that the tocopherol
concentrations were lower in all study groups than in
the control group, and it was identified that the
reduction in the diabetes and diabetes + TQ groups was
significant when compared to the control group (p ≤
0.05). It was identified that the vitamin D3 levels were
significantly lower in the study groups when compared
to the control group (p ≤ 0.05). It was identified that the
serum antioxidant vitamin levels decreased in the group
with experimental diabetes and that TQ administration
did not significantly affect the antioxidant vitamin
levels significantly in the group with experimental
diabetes.
Key words: experimental diabetes, antioxidant
vitamins, thymoquinone