© 2022 Wiley Periodicals LLC.Background: People who are compassionate to both themselves and others want to alleviate their experiences of pain and those of others. Aims: This study aims to evaluate the predictive effect of self-compassion on relationship satisfaction and conflict resolution styles in romantic relationships in nursing students. Methods: The sample of this study consists of 356 nursing students. The data are collected by using the Self-Compassion Scale, the Conflict Resolution Styles Scale in Romantic Relationships, and the Relationship Satisfaction Scale. A linear regression model is used to test the predictive effect of self-compassion on relationship satisfaction and conflict resolution styles in nursing students. Results: Mean age of the participant is 20.70 ± 1.90, 68.5% (n = 244) of the nursing students are female, and 33.2% of them (n = 211) are male. Self-compassion is found to be a significant predictor of both relationship satisfaction and conflict resolution styles (positive conflict resolution, negative conflict resolution, and retreat) in romantic relationships (p <.05). Conclusion: Self-compassion is an important factor in relationship satisfaction and conflict resolution. These results of the study can be used to address conflict resolution problems in romantic relationships and further research.