Akademik Veri Yönetim Sistemi
Alexandria Journal of Veterinary Sciences, cilt.77, sa.1, ss.21-29, 2023 (Hakemli Dergi)
This study was designed to reveal the diagnostic efficiency of total antioxidant capacity (TAC), total oxidant capacity (TOC), oxidative stress index (OSI), thiol/disulphide homeostasis (TDH), albumin (ALB) and ischaemia-modified albumin (IMA) parameters in the assessment of oxidative stress in dogs with babesiosis. While the babesiosis group consisted of a total of 7 dogs with clinical and parasitological (ELISA) diagnoses of babesiosis, the control group consisted of 7 healthy dogs. Blood samples were taken from both groups. While the levels of TAC, TOC and ALB in the blood serums of the groups were measured using a commercial kit, the levels of total thiol (TT), native thiol (NT) and IMA were measured using the method. The OSI and disulphide (Ds) levels were calculated using the formula. When compared with the control group, TAC and ALB levels significantly decreased, whereas the levels of TOC and OSI elevated in the babesiosis group (p<0.05). No difference was found between the groups in terms of NT, TT, Ds, and IMA levels and the ratios of NT/TT, Ds/TT, and Ds/NT (p˃0.05). A negative significant correlation was found between TAC and OSI and between Ds/NT and NT, TT and NT/TT (p<0.05; p<0.001, respectively). A significant positive correlation was found between NT and TT and NT/TT and between TT and NT/TT (p<0.001). The areas under the ROC curve of the variables TAC, TOC, OSI and ALB were found to be 0.918, 0.796, 0.980 and 1, respectively. The results showed that TAC, TOC, OSI and ALB performed diagnostically in the assessment of elevated oxidative stress in dogs with babesiosis.