Protective effect of dapagliflozin on colistin-induced renal toxicity

Bora E. S., ERDOĞAN M. A., Meral A., Karakaya Z., Erbas O.

SIGNA VITAE, cilt.17, sa.4, ss.92-97, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.22514/sv.2021.020
  • Dergi Adı: SIGNA VITAE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.92-97
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Objectives: Multiple-drug resistance to Gram-negative bacteria has increased significantly in recent years. Colistin is increasingly used as a last line of defense against these bacteria. However, colistin has been associated with nephrotoxicity in experimental animals. This study explores the protective effect of dapagliflozin in a rodent model of nephrotoxicity.