Dexamethasone-loaded chitosan-based genipin-cross-linked hydrogel for prevention of cisplatin induced ototoxicity in Guinea pig model


Aslier N. G. Y., Tagac A. A., Durankaya S. M., Calisir M., Ersoy N., KIRKIM G., ...Daha Fazla

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, cilt.122, ss.60-69, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 122
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.ijporl.2019.04.003
  • Dergi Adı: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.60-69
  • Anahtar Kelimeler: Cisplatin, Dexamethasone, Genipin, Guinea pig, Hydrogel, Ototoxicity, INNER-EAR, INTRATYMPANIC DEXAMETHASONE, CORTICOSTEROID PHARMACOKINETICS, ALPHA-TOCOPHEROL, MENIERES-DISEASE, HEARING-LOSS, PROTECTION, RESVERATROL, CHILDREN, DELIVERY
  • Van Yüzüncü Yıl Üniversitesi Adresli: Hayır

Özet

Objectives: The aim of this study was to investigate the protective effects of a sustained release form of dexamethasone (dex) loaded chitosan-based genipin-cross-linked hydrogel (CBGCH) in a guinea pig model of cisplatin (CP) induced hearing loss.