Dexamethasone-loaded chitosan-based genipin-cross-linked hydrogel for prevention of cisplatin induced ototoxicity in Guinea pig model


Aslier N. G. Y. , Tagac A. A. , Durankaya S. M. , Calisir M. , Ersoy N., KIRKIM G., ...More

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, vol.122, pp.60-69, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 122
  • Publication Date: 2019
  • Doi Number: 10.1016/j.ijporl.2019.04.003
  • Title of Journal : INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
  • Page Numbers: pp.60-69
  • Keywords: Cisplatin, Dexamethasone, Genipin, Guinea pig, Hydrogel, Ototoxicity, INNER-EAR, INTRATYMPANIC DEXAMETHASONE, CORTICOSTEROID PHARMACOKINETICS, ALPHA-TOCOPHEROL, MENIERES-DISEASE, HEARING-LOSS, PROTECTION, RESVERATROL, CHILDREN, DELIVERY

Abstract

Objectives: The aim of this study was to investigate the protective effects of a sustained release form of dexamethasone (dex) loaded chitosan-based genipin-cross-linked hydrogel (CBGCH) in a guinea pig model of cisplatin (CP) induced hearing loss.