Antiproliferative and Apoptotic Role of Novel Synthesized Cu(II) Complex with 3-(3-(4-fluorophenyl)Triaz-1-en-1-yl) Benzenesulfonamide in Common Cancer Models.

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Tuluce Y., Gorgisen G., Gulacar I., Koyuncu I., Durgun M., Akocak S., ...Daha Fazla

Anticancer research, cilt.38, ss.5115-5120, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38
  • Basım Tarihi: 2018
  • Doi Numarası: 10.21873/anticanres.12832
  • Dergi Adı: Anticancer research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.5115-5120
  • Anahtar Kelimeler: Metal complexes, anticancer compounds, copper complexes, apoptosis, METAL-COMPLEXES, COPPER, SULFONAMIDES, TRIAZENES
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Abstract

Background/aim: Chemotherapeutic treatment options are often ineffective due to the development of resistance in cancer cells. Therefore, developing new anti-cancer agents is crucial for cancer treatment. Some triazine derivatives, their complexes and Copper(II) have anti-cancer effects on cancer cells. In this study, we aimed to determine the anti-proliferative effect of the novel synthesized Cu(II) complex with 3-(3-(4-fluorophenyl)triaz-1-en-1-yl) benzene-sulfonamide compound on the common cancer cell lines HeLa, MDA-MB-231, A2780 and MCF7.

Materials and methods: Common cancers cell lines were treated with copper complexes. Cell viability and apoptotic gene expression were examined.

Results: Novel synthesized copper complex led to decreased viability of all cell lines. It also induced apoptosis via increasing the expression of caspase-3, caspase-9, Bax and p53 proteins and decreasing ERK expression.

Conclusion: The novel synthesized copper complex has a significant inhibitory effect on the viability of cancer cell lines and can be considered as an antitumor agent for further studies.

Keywords: Metal complexes; anticancer compounds; apoptosis; copper complexes.