The Protective Effect of Losartan on Diabetic Neuropathy in a Diabetic Rat Model

ÇAVUŞOĞLU T., KARADENIZ T., CAGILTAY E., KARADENIZ M., Yigitturk G., Acikgoz E., ...Daha Fazla

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, cilt.123, sa.8, ss.479-484, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 123 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1055/s-0035-1550019
  • Dergi Adı: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.479-484
  • Anahtar Kelimeler: medicine, losartan, diabetes, electromyography, histopathological, NERVE GROWTH-FACTOR, ANGIOTENSIN-II, ACE-INHIBITOR, RISK-FACTORS, BLOOD-FLOW, LISINOPRIL, BLOCKADE, MECHANISMS, NEURONS, BDNF
  • Van Yüzüncü Yıl Üniversitesi Adresli: Hayır

Özet

Aim: Involvement of the peripheral and autonomic nervous systems is possibly the most frequent complication of diabetes. Important risk factors included hyperglycemia, dyslipidemia, hypertension, and smoking. Angiotensin-converting-enzyme inhibitor (ACE) inhibitors should be beneficial in all vascular beds, including neuropathy and retinopathy. In this study we aimed to evaluate the effect of the angiotensin receptor blocker losartan on diabetic neuropathy in a diabetic rat model.