Synthesis of 2‐Methyl‐pyran‐4‐ones through Reaction of Acetylketene with Terminal Acetylenes in Presence of Gold (I)


Aslanoğlu F.

CHEMISTRYSELECT, vol.7, pp.1-4, 2022 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2022
  • Doi Number: 10.1002/slct.202201089
  • Journal Name: CHEMISTRYSELECT
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier
  • Page Numbers: pp.1-4
  • Keywords: acetylketene, gold(I), 2-methyl-pyran-4-one, terminal acetylenes, 2, 2, 6-trimethyl-4H-1, 3-dioxin-4-one, CYCLOADDITIONS

Abstract

In this study, 2,6‐trimethyl‐4H‐1,3‐dioxin‐4‐one compound, which is a source of Acetylketene, was reacted with terminal alkynes in presence of IPrAuCl (1,3‐Bis(2,6‐diisopropylphenyl‐imidazol‐2‐ylidene)gold(I) chloride) catalyst and a new synthesis method for 2‐methyl‐pyran‐4‐one compounds has been developed. It was observed that the yields were very low when this reaction was carried out without using a catalyst. However, 95 % yield was obtained when this reaction was performed in the presence of a IPrAuCl catalyst