Xenograft Tumor Volume Measurement in Nude Mice: Estimation of 3D Ultrasound Volume Measurements Based on Manual Caliper Measurements


BARIŞ M. M. , Serinan E., Calisir M. , Simsek K., AKTAŞ S., YILMAZ O., ...More

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, vol.4, no.2, pp.90-95, 2020 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.30621/jbachs.2020.902
  • Title of Journal : JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Page Numbers: pp.90-95
  • Keywords: Tumor volume, nude mice, ultrasonography, 3-D imaging, laboratory animal science, TESTICULAR VOLUME, BONE-MARROW, FORMULAS

Abstract

Objectives: Volume measurement of subcutaneous xenograft tumors in nude mice models is an important metric to assess tumor growth or response to therapy. Manual calipers are widely used for this purpose. But the measurements with manual calipers may be inaccurate. Contrarily, three-dimensional (3D) ultrasonographic measurements give reliable and accurate tumor volume calculation. We aim to; evaluate the accuracy of common four formulas given in the literature to estimate xenograft tumor volumes based on manual caliper measurements and offer a new coefficient for a better estimation of the tumor volumes.