Determination of serum cardiac biomarkers and plasma D-dimer levels in anemic sheep with babesiosis

ORUNC KILINC O., Göz Y., Yüksek N., Başbuğan Y., Yılmaz A. B., ATAŞ A. D.

TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES, vol.39, no.5, pp.606-610, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.3906/vet-1501-105
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.606-610
  • Keywords: Babesia, cardiac biomarkers, D-dimer, hematocrit, sheep, TROPONIN-I, CANINE BABESIOSIS, DISEASE, IDENTIFICATION, RUMINANTS, THEILERIA, CATTLE, BOVIS
  • Van Yüzüncü Yıl University Affiliated: Yes


In this study, the cardiac effects of anemia and venous thromboembolism (VTE), reportedly caused by the hemolyzed erythrocytes occurring in sheep with babesiosis, were investigated using cardiac markers and D-dimer (DD). The study included 34 sheep: 24 infected Akkaraman sheep (1-3 years old, diagnosed with babesiosis based on clinical and laboratory findings) and a control group of 10 noninfected healthy sheep of the same breed and age. Hematocrit (Hct) levels were measured in blood obtained from both groups. Cardiac troponin I (cTnI), creatine kinase-MB (CK-MB), and aspartate aminotransferase (AST) levels were measured in serum samples. In addition, the levels of DD were also measured in plasma samples. Sheep with babesiosis were subsequently divided into 3 subgroups according to their Hct levels, which ranged from 13.2% to 16.3% in the first group (n = 8), 20.1% to 25.6% in the second group (n = 8), and 27.4% to 30.3% in the third group (n = 8). Evaluations of the measurements of cTnI, CK-MB, and AST levels indicated statistically significant differences between infected and healthy sheep. Statistically significant differences were not found for DD levels between the 2 groups.