Akademik Veri Yönetim Sistemi
Chemistry & Biodiversity, cilt.18, sa.6, ss.34, 2021 (SCI-Expanded)
Gundelia species are known as "Kenger-kereng dikeni" in Anatolia, and their aerial parts are consumed as food. Also, roots and seeds (disseminules) of the Gundelia species are used to prepare gum and coffee. The chemical contents of ethanol and hexane extracts of disseminules of 17 Gundelia species, 13 of them are endemic, were studied using LC-MS/MS and GC-MS. Additionally, their antioxidant potential and enzyme inhibitory capacity against acetyl- and butyryl-cholinesterase, urease, and tyrosinase were determined. The unsaturated fatty acid ratios of Gundelia species were higher than their saturated fatty acid ratio. The highest sum of oleic and linoleic acid was detected in G. tournefortii var. tenuisecta (70.42%). β -Sitosterol, α -amyrin, 3-acetyl-lupeol were identified in 17 Gundelia species by GC-MS, while chlorogenic acid and luteolin by LC-MS/MS as major compounds. The ethanol and hexane extracts of G. siirtica , G. rosea , and G. mesopotamica indicated good cholinesterase inhibitory activity. Among all species, ethanol extract of G. colemerikensis exhibited the best activity in ABTS (IC 50 : 32.30±0.98 μg/mL), DPPH (IC 50 : 59.91±0.89 μg/mL), and CUPRAC (A 0.5 : 57.41±1.03 μg/mL) assays. Ethanol extract of G. colemerikensis also displayed the highest inhibitory activity against butyrylcholinesterase (51.14±0.25% at 200 µg/mL), urease (51.71±1.75% at 200 µg/mL), and tyrosinase (39.50±0.85% at 200 µg/mL) enzymes. According to the chemometric analysis of fatty acids, four groups were observed. Therefore, it is suggested that G. colemerikensis can be used in the pharmaceutical, food, and cosmetic industries due to its antioxidant and enzyme inhibition properties.