Electrochemical Behaviour of Ofloxacin in Pharmaceutical and Biological Samples Using a Boron-Doped Diamond Electrode in Using Anionic Surfactant

Talay Pınar P.

GAZI UNIVERSITY JOURNAL OF SCIENCE, cilt.31, sa.1, ss.66-80, 2018 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 1
  • Basım Tarihi: 2018
  • Dergi Adı: GAZI UNIVERSITY JOURNAL OF SCIENCE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.66-80
  • Anahtar Kelimeler: Ofloxacin, Sodium Dodecyl Sulfate, Boron-Doped Diamond Electrode, Square-Wave Voltammetry, Biological and Pharmaceutical Samples, PERFORMANCE LIQUID-CHROMATOGRAPHY, SQUARE-WAVE VOLTAMMETRY, SODIUM DODECYL-SULFATE, STRIPPING VOLTAMMETRY, HUMAN URINE, CAPILLARY-ELECTROPHORESIS, SPECTROPHOTOMETRIC DETERMINATION, FLUORESCENCE DETECTION, CATIONIC SURFACTANT, GRAPHITE ELECTRODE
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

This paper examined use of a boron doped diamond electrode (BDDE) for the electroanalysis of ofloxacin (one of the fluoroquinolone compounds) by cyclic voltammetry (CV) and square wave voltammetry (SWV) in the presence of anionic surfactant (sodium dodecyl sulfate, SDS). The current signal due to the oxidation process was a function of the amount of ofloxacin, pH of the medium, effect of SDS and scan rate. Cyclic voltammetric studies indicated an irreversible behaviour of ofloxacin in phosphate buffer solution at pH 2.0 with well-defined oxidation peak at + 1.24 V (absence SDS) and + 1.21 V (presence of SDS) vs. Ag/AgCl, respectively. With optimized experimental parameters, the current response of ofloxacin was proportionally linear in the concentration range from 1.0x10(-7) to 3.5x10(-6) M. A detection limit of 1.76x10(-8) M was observed anodically electrochemical surface pretreatments. The practical applicability of the developed method was demonstrated on the determination of ofloxacin in human urine and pharmaceutical samples. In this way, BDD electrode may represent an efficient alternative to widely used modified electrodes in the determination of fluoroquinolone compounds.