Borax exerts protective effect against ferrocene-induced neurotoxicity in Oncorhynchus mykiss

Yeltekin A. Ç. , UÇAR A., PARLAK V., ÖZGERİŞ F. B. , TÜRKEZ H., ESENBUĞA N., ...More

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, vol.72, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72
  • Publication Date: 2022
  • Doi Number: 10.1016/j.jtemb.2022.126996
  • Journal Indexes: Science Citation Index Expanded, Scopus, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Fish, Boron supplementation, Sustainable ecosystems, Rainbow trout, Brain, Neuroprotective action, NEUROTROPHIC FACTOR, RAINBOW-TROUT, BRAIN, BDNF, TOXICITY, EXPRESSION, DISEASE, INJURY


Background: In recent years, therapeutic targets and the development of new drugs have shifted research towards inflammatory and oxidative stress pathways. Ferrocene (FcH) is a stable, small molecule that exhibits immunostimulatory and anti-tumor properties by a different mechanism and is effective at low doses in oral administration. However, it was surprising that there has been no performed investigation using FcH on aquaculture. On the other hand, recent papers reveal the key biological functions and health benefits due to daily boron intake in animals and humans. Therefore, we investigated the neurotoxic damage potential of FcH and its related neurotoxicity action mechanism in aquatic environments. In addition, the protective potential of borax (BX, or sodium borate) were evaluated againt in vivo neurotoxicity by FcH.