International Conference on Multidisciplinary, Science, Engineering and Technology (IMESET’17 Bitlis) Oct 27-29, 2017, Bitlis, Bitlis, Turkey, 27 - 29 October 2017, pp.187
According to the Diabetes Atlas 2016 of International Diabetes Federation (IDF), there are 415 million diabetics in the World. It is estimated that this number will reach 642 million by 2040. According to 2015 data of Adress based population registration system of Turkish Statistical Institute (TUIK); In 2014, the proportion of people with diabetes in Turkey is 9%. Diabetes, a chronic disease, is responsible for millions of deaths each year and limits the lives of many people with life-threatening complications. Herbs and their derivatives have been used for many years in the treatment of DM and are thought to be less toxic and less side effect than synthetic ones. Scientific studies have been carried out on plants that may be alternative to synthetic drugs used in the treatment of diabetes worldwide. In this study, Vicia ervilia seed extract, traditionally used in the treatment of diabetes, was administered orally to the experimental diabetic rats at 3 different doses for 25 days. The effect of the extract on liver damage, one of the complications that may develop depending on the diabetes, was investigated. At the end of the experimental period, serum alanin aminotransferase (ALT) and aspartat aminotransferase (AST) levels, which are accepted as liver damage biomarkers, showed statistically significant increase (p ≤ 0.05) in diabetic groups compared to normal control group. Serum ALT, AST and lactate dehydrogenase (LDH) values were statistically significant decrease (P ≤ 0.05) in all diabetic groups treated with seed extract compared to diabetic control group.
Key words: Diabetes mellitus, liver damage, Küşne, Rats, Vicia ervilia