The effects of moxidectin nicotine-conditioned cue on nicotine-seeking behavior in mice


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Yunusoğlu O., Demirkol M. H., Berköz M., Sağmanlıgil V., Oto G., Özdemir H.

International Journal of Advanced and Applied Sciences, cilt.8, sa.12, ss.117-125, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 12
  • Basım Tarihi: 2021
  • Doi Numarası: 10.21833/ijaas.2021.12.014
  • Dergi Adı: International Journal of Advanced and Applied Sciences
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Directory of Open Access Journals
  • Sayfa Sayıları: ss.117-125
  • Anahtar Kelimeler: Nicotine addiction, Moxidectin, Conditioned place preference, ROSEA L. EXTRACT, PLACE PREFERENCE, ACQUISITION, EXPRESSION, REINSTATEMENT, WITHDRAWAL, ALCOHOL, BACLOFEN, RECEPTOR, REWARD
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

© 2021 The Authors. Published by IASE. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Current pharmacotherapies for nicotine abuse are few and relatively inefficient demonstrating the need for the development of new, effective remedies. Moxidectin is used as an anti-parasitic agent in both animals and humans, it also activates GABA receptors. The objective of the present investigation was to study the effect of moxidectin on nicotine-induced conditioned place preference (CPP) in male Swiss mice. Intraperitoneal (i.p.) route was used for nicotine (0.5mg/kg) administration for a 3-day conditioning program. The influences of moxidectin on the reinforcing characteristics of nicotine were tested in mice given i.p. treatment of moxidectin (5 and 10mg/kg) 30 minutes prior to per nicotine administration. CPP was extinguished by repeated testing, through which conditioned mice were daily given two doses of moxidectin (5 and 10mg/kg, i.p.). Subsequently, the potency of moxidectin in blocking the reinstatement of CPP provoked by priming given low-dose nicotine (0.1mg/kg, i.p.) was also evaluated. Moxidectin treatment illustrated a reserve of acquisition of nicotine-induced CPP. It was reduced priming nicotine-induced reinstatement and accelerated the extinction of CPP. Relatively nicotine enhanced the locomotor, motor activity but was not statistically significant. In conclusion, the outcomes demonstrate the potential for the development of moxidectin as a new pharmacotherapy for the treatment of nicotine addiction.