DNA binding studies of the 2,10,16,24-tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

Balli Z., Arslantas A., Solgun D., Ağırtaş M. S.

SN APPLIED SCIENCES, cilt.2, sa.5, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s42452-020-2640-4
  • Dergi Adı: SN APPLIED SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, INSPEC
  • Anahtar Kelimeler: Aggregation, Synthesis, Absorption spectroscopy, DNA binding, Gel electrophoresis, Phthalocyanine, DISUBSTITUTED SILICON PHTHALOCYANINES, TOPOISOMERASE-I, PHOTOCLEAVAGE, DERIVATIVES, COMPLEXES, MECHANISM, INHIBITION, PORPHYRIN, VISCOSITY, NUCLEASE
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Tetra phenoxy-3-methoxybenzoic acid substituted Co(II) and Cu(II) metal phthalocyanine compounds were reported for the first time. The structures of these compounds were elucidated by NMR, FT-IR, UV-vis spectroscopy, and elemental analysis. The UV/Vis, fluorescence spectra, viscosity and the thermal melting point techniques were implemented to analyze the DNA bonding activities of cobalt (II) and copper (II) complexes of phthalocyanine by calf thymus DNA. These techniques showed that the phthalocyanine complexes interacted with the DNA molecule through the intercalation mechanism. Additionally, among the methods above, the binding properties of DNA with the compounds 4 and 5 were studied by means of the agarose gel electrophoresis method. The complexes 4 and 5 bonded to the DNA molecule in the buffer system at a pH of 7.02. The findings of these methods proved that the Co(II) and Cu(II) complexes of phthalocyanine could be evaluated as potential cancer medicine for cancer treatment in the near future.