Akademik Veri Yönetim Sistemi
Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, cilt.10, sa.3, ss.1848-1856, 2020 (Hakemli Dergi)
Angiotensin converting enzyme (ACE, peptidyldipeptidase A, EC 3.4.15.1) has got a
significant role in the arrangement of blood pressure. ACE inhibitors usually play a part in the therapies
of hypertension. Hypertension is an significant cardiovascular risk factor. The main purpose of the
treatment is to reduce the incidence of hypertension. In this study, the inhibition effect of butanol and
water extracts of Thymbra sintenisii Bornm. et Aznav. Subsp on angiotensin converting enzyme (ACE)
activity in human plasma was investigated. ACE activity was calculated at 345 nm
spectrophotometrically. Extracts of Thymbra sintenisii Bornm. et Aznav. subsp plant with water and
butanol were made. The effectiveness of these extracts on ACE activity was researched. Water and
butanol extracts of Thymbra sintenisii indicated inhibition impact on ACE. IC50 values for water and
butanol extracts of Thymbra sintenisii was measured to be 1.696 mg mL-1
and 0.395 mg mL-1
respectively. Inhibition type for water and butanol extracts of Thymbra sintenisii from Lineweaver-Burk
chart was defined to be non-competitive inhibition. Synthetic ACE inhibitors are utilized in the therapy
of hypertension. On the other hand, synthetic ACE inhibitors exhibit a large number of adverse effects.
Therefore, ACE inhibitors have been newly researched from native herbs. These conclusions
demonstrate that water and butanol extracts of Thymbra sintenisii plant may have an ACE inhibition
capacity.