Role of vitamin E in decreasing the toxic effect of digoxin

Meral I., Baydas B., Bayiroglu F., Uysal H.

TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES, cilt.23, sa.5, ss.445-450, 1999 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 5
  • Basım Tarihi: 1999
  • Dergi Adı: TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.445-450
  • Van Yüzüncü Yıl Üniversitesi Adresli: Hayır

Özet

This experiment was carried out to evaluate the role of Vitamin E in decreasing the toxic effect of digoxin. Electrocardiographic recordings of New Zealand rabbits which were treated with digoxin-only or digoxin+vitamin E were used. Recordings were obtained before and 24 hours after treatments. It was found that digoxin-only treatment caused a sinusoidal tachicardia without changing the durations or amplitudes of any wave on the trace. However, digoxin+vitamin E treatment did not produce any increase in heart rate. It was concluded that Vitamin E injection along with digoxin injection might lower the toxic effect of digoxin. More studies are needed to convince these findings.