Cyclosporine reduces hepatic antioxidant capacity: protective roles of antioxidants


Durak I., Ozbek H., Elgun S.

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.4, no.3, pp.469-473, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1016/j.intimp.2004.01.018
  • Title of Journal : INTERNATIONAL IMMUNOPHARMACOLOGY
  • Page Numbers: pp.469-473

Abstract

The immunosuppressive agent cyclosporine A (CsA) has been reported to exert measurable hepatotoxic effects. One of the causes leading to hepatotoxicity is thought to be reactive oxygen radical formation. Therefore, this study was designed to elucidate possible relation between cyclosporine A treatment and antioxidant capacity (AOC) of hepatic tissue and, to determine if antioxidant supplementation is beneficial.