Cyclosporine reduces hepatic antioxidant capacity: protective roles of antioxidants


Durak I., Ozbek H., Elgun S.

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.4, ss.469-473, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 4 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.intimp.2004.01.018
  • Dergi Adı: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Sayfa Sayıları: ss.469-473

Özet

The immunosuppressive agent cyclosporine A (CsA) has been reported to exert measurable hepatotoxic effects. One of the causes leading to hepatotoxicity is thought to be reactive oxygen radical formation. Therefore, this study was designed to elucidate possible relation between cyclosporine A treatment and antioxidant capacity (AOC) of hepatic tissue and, to determine if antioxidant supplementation is beneficial.