Cyclosporine reduces hepatic antioxidant capacity: protective roles of antioxidants

Durak I., Ozbek H., Elgun S.

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.4, sa.3, ss.469-473, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.intimp.2004.01.018
  • Sayfa Sayıları: ss.469-473


The immunosuppressive agent cyclosporine A (CsA) has been reported to exert measurable hepatotoxic effects. One of the causes leading to hepatotoxicity is thought to be reactive oxygen radical formation. Therefore, this study was designed to elucidate possible relation between cyclosporine A treatment and antioxidant capacity (AOC) of hepatic tissue and, to determine if antioxidant supplementation is beneficial.