Antinociceptive and anti-inflammatory activities of Viburnum opulus

Altun M. L., Citoglu G. S., Yilmaz B. S., Ozbek H.

PHARMACEUTICAL BIOLOGY, vol.47, no.7, pp.653-658, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 7
  • Publication Date: 2009
  • Doi Number: 10.1080/13880200902918345
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.653-658
  • Van Yüzüncü Yıl University Affiliated: Yes


Water extract of Viburnum opulus L. (Caprifoliaceae) (VO) leaf was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that VO causes dose related inhibition in acetic acid-induced abdominal stretching in mice. VO inhibited abdominal stretching at 100 and 200 mg/kg. VO showed antinociceptive activity, which was quantified by the tail-flick test at doses of 100 and 200 mg/kg. However, VO did not have an anti-inflammatory effect at these doses. The LD50 of VO was determined as 5.447 g/kg.