Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives


Akbas E., Berber I.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.40, ss.401-405, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 40 Konu: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.ejmech.2004.12.001
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Sayfa Sayıları: ss.401-405

Özet

Several new pyrazolo[3,4-d]pyridazin derivatives were prepared by the reaction of two new 1H-pyrazole-3-carboxylic acids and various hydrazines. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi. The compounds named as 7e, f had the highest antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi with minimum inhibitory concentrations in the range of 0.31 to < 0.0024 mg ml(-1). (c) 2005 Elsevier SAS. All rights reserved.