Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives

Akbas, E; Berber, I

doi:10.1016/j.ejmech.2004.12.001

Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives

Copy For Citation

Akbas E., Berber I.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.40, no.4, pp.401-405, 2005 (SCI-Expanded)

Publication Type: Article / Article
Volume: 40 Issue: 4
Publication Date: 2005
Doi Number: 10.1016/j.ejmech.2004.12.001
Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.401-405
Van Yüzüncü Yıl University Affiliated: No

Abstract

Several new pyrazolo[3,4-d]pyridazin derivatives were prepared by the reaction of two new 1H-pyrazole-3-carboxylic acids and various hydrazines. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi. The compounds named as 7e, f had the highest antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi with minimum inhibitory concentrations in the range of 0.31 to < 0.0024 mg ml(-1). (c) 2005 Elsevier SAS. All rights reserved.