Hepatoprotective and TNF-alpha inhibitory activity of Zosima absinthifolia extracts and coumarins

Bahadir O., Citoglu G. S., Ozbek H., Dall'Acqua S., Hosek J., Smejkal K.

FITOTERAPIA, vol.82, no.3, pp.454-459, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1016/j.fitote.2010.12.007
  • Journal Name: FITOTERAPIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.454-459
  • Van Yüzüncü Yıl University Affiliated: Yes


Zosima absinthifolia (ZA) extracts and the coumarins (+)-columbianadin and (-)-deltoin were evaluated for their potential hepatoprotective and antiinflamatory effects in a CCl4-induced hepatotoxicity assay in rats and by the inhibition of TNF-alpha production on LPS-stimulated THP-1 macrophages, respectively. Both the ZA extracts and the coumarins showed hepatoprotective activity confirmed by monitoring the ALT/AST levels and by histopathological examination. The antiinflamatory activity, proved by the inhibition of TNF-alpha production, was found to be higher for the n-hexane root extract than for coumarins, suggesting synergic potential of the extract. The concentration of (-)-deltoin and (+)-columbianadin in extracts was determined by HPLC analysis. (c) 2011 Elsevier B.V. All rights reserved.