A genome screen for linkage disequilibrium in Turkish multiple sclerosis

Eraksoy M., Hensiek A., Kurtuncu M., Akman-Demir G., Kilinc M., Gedizlioglu M., ...Daha Fazla

JOURNAL OF NEUROIMMUNOLOGY, cilt.143, ss.129-132, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 143
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/j.jneuroim.2003.08.027
  • Dergi Adı: JOURNAL OF NEUROIMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.129-132
  • Van Yüzüncü Yıl Üniversitesi Adresli: Hayır

Özet

In order to screen the Turkish population for evidence of association with multiple sclerosis, we typed 6000 microsatellite markers in separately pooled DNA samples from 197 cases and 199 controls following the Genetic Analysis of Multiple sclerosis in Europeans (GAMES) protocol. Twelve markers showing evidence for association were identified. One of these markers lying directly in a region which is also implicated in the Turkish linkage screen (chromosome 5p15) and thus shows evidence for both linkage and association in independent data sets. (C) 2003 Elsevier B.V. All rights reserved.