Determination of indacaterol from inhaler capsules by square-wave voltammetry at the surface of the boron-doped diamond electrode ОДРЕЂИВАЊЕ ИНДАКАТЕРОЛА НА ПОВРШИНИ БОРОМ ДОПИРАНЕ ДИЈАМАНТСКЕ ЕЛЕКТРОДЕ, У КАПСУЛАМА ЗА ИНХАЛАЦИЈУ, КОРИШЋЕЊЕМ ВОЛТАМЕТРИЈЕ ПРАВОУГАОНИХ ТАЛАСА

Barzani H. A. H., Ali H. S., Yardım Y.

Journal of the Serbian Chemical Society, cilt.90, sa.1, ss.77-94, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 90 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.2298/jsc240221090b
  • Dergi Adı: Journal of the Serbian Chemical Society
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Central & Eastern European Academic Source (CEEAS), Chemical Abstracts Core, Communication Abstracts, Food Science & Technology Abstracts, Metadex, Directory of Open Access Journals, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.77-94
  • Anahtar Kelimeler: boron-doped diamond electrode, indacaterol maleate, inhaler capsules, square-wave voltammetry
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

This research paper presents an electroanalytical investigation using the voltammetric method to quantify indacaterol maleate (IND) employing an unmodified boron-doped diamond (BDD) electrode. IND exhibited a distinct, irreversible oxidation peak at approximately 1.06 V (vs. Ag/AgCl) in a 0.1 mol L-1 phosphate buffer solution (PBS) with a pH of 2.5, as demonstrated by cyclic voltammetry (CV). A hypothetical mechanism for the electro-oxidation of IND, based on data gathered from CV investigations, was suggested. The square wave-adsorptive stripping voltammetric technique achieved acceptable linearity in PBS (pH 2.5) at approximately 0.90 V. The methodology demonstrated linearity within the concentration range of 1.0 to 30.0 ?g mL-1 (equivalent to 1.97×10-6–5.89×10-5 mol L-1) and yielded a limit of detection (LOD) of 0.22 ?g mL-1 (equivalent to 4.33×10-7 mol L-1). The proposed method’s applicability was assessed through the sensing of IND in drug formulations.