Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, vol.10, no.2, pp.54-61, 2020 (Peer-Reviewed Journal)
In this study, we aimed to determine the hepatoprotective and antioxidants role of thyme (O. onites)
against ethyl alcohol (EtOH) induced oxidative stress in rats. The experiment conducted as control, 20%
EtOH, 3% O. onites infusion and 3% O. onites + 20% EtOH groups. The antioxidant and
hepatoprotective role of O. onites infusion was evaluated by histopathological chance and serum damage
biomarkers of liver (LDB), antioxidant constituents (ACs) and malondialdehyde (MDA). According to
results, Liver damage serum enzymes activities were significantly higher in 20% EtOH group compared
to normal control (NC) whereas the parameters were significantly lower in the infusion supplemented
groups compared to 20% EtOH group. Also, MDA content of 20% EtOH group increased significantly
in all tissues compared to NC group but decreased as comparison with 20% EtOH. The results suggest
that the infusion restored the most of the parameters towards the NC with fluctuations in the ACs.