Use of an antiarrhythmic drug against acute selenium toxicity

Yücel U. M., Başbuğan Y., Uyar A., Kömüroğlü A. U., Keleş Ö. F.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, cilt.59, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.jtemb.2020.126471
  • Dergi Adı: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Selenium, Amiodarone, Acute toxicity, Survival rate, AMIODARONE, METABOLISM, RATS, TRIMETHYLSELENONIUM, DYSFUNCTION, LIVER, NANOPARTICLES, PREVENTION, EXCRETION, COPPER
  • Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Objective: Selenium is an essential trace element. But, selenium may have toxic effects in high doses. There are no proven antidotes or curative treatments for acut selenium toxicity. Treatment involves stopping the exposure and providing supportive care for symptoms. Therefore, it is necessary to find more effective substances in the treatment of selenium toxicity. The aim of this study was to increase the survival rate of animals by supporting the heart with amiodarone and to determine the effect of amiodarone on the pathological, hematological and biochemical parameters in acute selenium intoxication.