Design, synthesis, and antiproliferative activities of novel thiazolyl-pyrazole hybrid derivatives

Kuzu B., Ergüç A., Karakuş F., Arzuk E.

Medicinal Chemistry Research, vol.32, no.8, pp.1690-1700, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 8
  • Publication Date: 2023
  • Doi Number: 10.1007/s00044-023-03090-2
  • Journal Name: Medicinal Chemistry Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, Veterinary Science Database
  • Page Numbers: pp.1690-1700
  • Keywords: ADMET, Antiproliferation, SAR, Thiazolyl-pyrazole
  • Van Yüzüncü Yıl University Affiliated: Yes


In this study, a series of derivatives of thiazolyl-pyrazole hybrid structures were designed to search for new heterocyclic compound-based antitumor agents. The designed target structures were synthesized with easy, practical, and efficient procedures. The antiproliferative effect of the synthesized compounds against cancer cell lines A549, MCF-7, and HepG2 was evaluated regarding inhibition concentration and selectivity index against healthy cell line CCD-34Lu. The results overall showed that the compounds had high antiproliferation against cancer cells compared to the doxorubicin-positive control. In particular, compound 11 A549 (SI: 3.58) and HepG2 (SI: 12.36) had high selectivity in cancer cell lines, while compounds 10h and 10o had high selectivity (SI: 10.74 for both) in MCF-7 cancer cell lines. The calculated theoretical pharmacokinetic properties revealed that they could be suitable drug candidates. In addition, in vitro test results indicate a correlation between the structure-activity relationships of the compounds. The various molecular modifications of thiazolyl-pyrazole hybrid compounds are promising for developing new anticancer drug candidates. Graphical Abstract: [Figure not available: see fulltext.].