Cyclization Reactions of N-Propargyl-pyrazole-5-carboxylate Derivatives with Hydrazine Hydrate: Experimental and Theoretical Investigations

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Atıf İçin Kopyala

Tan Uygun M., Mengeş M. F.

12. Uluslararası İlaç Kimyası Kongresi, Antalya, Türkiye, 7 - 10 Mart 2024, ss.64

• Yayın Türü: Bildiri / Özet Bildiri
• Basıldığı Şehir: Antalya
• Basıldığı Ülke: Türkiye
• Sayfa Sayıları: ss.64
• Van Yüzüncü Yıl Üniversitesi Adresli: Evet

Özet

Pyrazole derivatives, particularly fused ones, have garnered significant interest for their diverse biological activities, especially potential anticancer agents. Despite the existing body of research, pyrazolo-pyrazinones remain underexplored in the literature, lacking reported methods for achieving high yields in synthesizing pyrazolo[1,5-a]pyrazines. Our study uniquely addresses this gap by investigating the reaction of the pyrazole ring with hydrazine hydrate, an uncharted pathway. This direct ring closure reaction, not previously explored, adds a novel dimension to the synthesis of pyrazolo-pyrazinones.