The effect of high dose digoxin on cytokines in healthy dogs

DULGER H., Sekeroglu M. R., ERYONUCU B., NOYAN T., ALICI U.

MEDIATORS OF INFLAMMATION, vol.11, no.4, pp.261-263, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 4
  • Publication Date: 2002
  • Doi Number: 10.1080/096293502900000122
  • Journal Name: MEDIATORS OF INFLAMMATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.261-263
  • Van Yüzüncü Yıl University Affiliated: Yes

Abstract

Background: Tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta are pro-inflammatory cytokines, causing myocardial dysfunction and a negative inotropic effect. The drugs used to treat heart failure affect the production of cytokines. Digoxin, on which this study was focused, is one of the drugs for the treatment of heart failure.