Vortioxetine-Induced Amenorrhea: A Case Report.

Işık M., Kurhan F., Ülkevan T., Özdemir P.

Clinical neuropharmacology, vol.45, no.1, pp.7-8, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1097/wnf.0000000000000490
  • Journal Name: Clinical neuropharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE, MLA - Modern Language Association Database, Psycinfo
  • Page Numbers: pp.7-8
  • Keywords: vortioxetine, amenorrhea, adverse effect
  • Van Yüzüncü Yıl University Affiliated: Yes


Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.BACKGROUND: Vortioxetine is a novel multimodal antidepressant for the treatment of major depressive disorders and is widely used in clinical practice. Vortioxetine has a safe profile. However, there are case reports of other adverse effects in the literature. In this article, a case of amenorrhea due to vortioxetine is presented. CASE: The patient is 36 years old, married, female, and is an anesthesiologist. She applied to the psychiatric outpatient clinic with symptoms of major depression. Vortioxetine was initiated at 10 mg/d and then gradually increased to 20 mg/d. She had regular menstruation until now. However, she did not menstruate after taking vortioxetine. The patient used vortioxetine for 3 months and never had a period. Pregnancy test and other tests to investigate organic etiology were normal. Two weeks after discontinuation of vortioxetine, the patient had a menstrual period. CONCLUSIONS: Further research is needed on the relationship and possible mechanisms between vortioxetine and amenorrhea.