© 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Treatment planning systems (TPS) have an important role in the implementation of radiotherapy treatment. Quality control of TPS is extremely important in terms of treatment reliability. In this study, it was aimed to make quality control of TPS by comparing the data obtained from the PROWESS Panther TPS with the results of the Monte Carlo simulation for small fields. In this study, TPS used in the radiation oncology department was examined. For MC simulation, BEAMnrc and DOSXYZnrc codes were used in modeling and dose measurement of linear accelerator device. Gamma analysis method was used to compare measurement results. When we examine the gamma analysis for PDDs in the study, the gamma values obtained in the 3x3 cm2, 4x4 cm2 and 5x5 cm2 field sizes for the 3% and 3mm criterion provide this criterion for each measurement point. The fact that each dose point in the measurement field is less than 0.1 gamma value indicates that the dose profiles obtained in PROWESS Panther TPS are in good agreement with the MC results. The doses calculated by PROWESS Panther TPS were found within the reference limits. It can be concluded that the dose calculated by PROWESS Panther TPS in homogeneous environments is within acceptable limits for use in radiotherapy. Studies should also be carried out in non-homogeneous environments such as lung, bone and soft tissue in order to obtain more accurate results about PROWESS Panther TPS.