Effect of sodium butyrate on some alternative splicing genes and BACE1 isoforms in Sh-Sy5y cell line

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Luleyap U., Aksoy G., Evyapan G., PAZARCI P., ALPTEKİN D., PAZARBAŞI A., ...More

CUKUROVA MEDICAL JOURNAL, vol.46, no.2, pp.764-771, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.17826/cumj.870361
  • Journal Name: CUKUROVA MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.764-771
  • Keywords: Alzheimer's disease, alternative splicing, sodium butyrate, HISTONE DEACETYLASES, ALZHEIMERS-DISEASE, CANCER-THERAPY, INHIBITION, APOPTOSIS, IDENTIFICATION, QUADRUPLEX
  • Van Yüzüncü Yıl University Affiliated: No

Abstract

Purpose: The aim of this study is to investigate effect of sodium butyrate (NaB), which is a Histon Deacetylase (HDAC) inhibitor, on BACE1 isoforms BACE1/501, BACE1/457 and BACE1/432 and alternative splicing factors including hnRNP H, U2AF35, U2AF65, SRSF1, SRSF2, SRSF5 and SRSF6.