Effect of sodium butyrate on some alternative splicing genes and BACE1 isoforms in Sh-Sy5y cell line

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Luleyap U., Aksoy G., Evyapan G., PAZARCI P., ALPTEKİN D., PAZARBAŞI A., ...Daha Fazla

CUKUROVA MEDICAL JOURNAL, cilt.46, sa.2, ss.764-771, 2021 (ESCI, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.17826/cumj.870361
  • Dergi Adı: CUKUROVA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.764-771
  • Anahtar Kelimeler: Alzheimer's disease, alternative splicing, sodium butyrate, HISTONE DEACETYLASES, ALZHEIMERS-DISEASE, CANCER-THERAPY, INHIBITION, APOPTOSIS, IDENTIFICATION, QUADRUPLEX
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Van Yüzüncü Yıl Üniversitesi Adresli: Hayır

Özet

Purpose: The aim of this study is to investigate effect of sodium butyrate (NaB), which is a Histon Deacetylase (HDAC) inhibitor, on BACE1 isoforms BACE1/501, BACE1/457 and BACE1/432 and alternative splicing factors including hnRNP H, U2AF35, U2AF65, SRSF1, SRSF2, SRSF5 and SRSF6.