Research Information System
Türk Doğa ve Fen Dergisi, vol.14, no.1, pp.48-57, 2025 (Peer-Reviewed Journal)
To investigate correlations between GST isozyme levels and tumor markers to evaluate the prognostic value of GST isozymes. This retrospective study analyzed clinical data from 40 patients with adenocarcinoma and squamous cell carcinoma. Tumor and adjacent healthy tissue samples were immunohistochemically stained to profile GST enzymes (Sigma, Omega, Pi, Mu) and caspase-3, Bcl-2, p38, p53. Associations between protein expression levels and patient characteristics were examined, and correlations between GST enzymes and Caspase-3, Bcl-2, p38, p53 were analyzed. Significant immunohistochemical differences were found between tumorous and healthy tissues for all markers. GST enzymes (GSTS, GSTO, GSTP, GSTM) were predominantly expressed in tumorous tissues, with GSTO and GSTP showing high expression levels. Compared to SCC tissues, GSTP expression is around 30% higher in AC tissues. In contrast, GSTO expression increases by around 25% in second-stage tumors, particularly in AC tissues. Correlation analysis revealed significant positive associations between Bcl-2 and caspase-3, p38, GSTS, between caspase-3 and GSTP, and between p38 and GSTM in tumor tissues. The study supports the prognostic value of GST isozymes in NSCLC.